Protein Details: Chloride channel protein

Protein ID

ICDB_Pro_0499

Protein Name

Chloride channel protein

Gene Name

Organism

Tetronarce californica (Pacific electric ray) (Torpedo californica)

Length

810 amino acids

AlphaFoldDB

AF-P35522-F1-model_v4.pdb

Function

This channel is thought to ensure the high conductance of the non-innervated membrane of the electrocyte necessary for efficient current generation caused by sodium influx through the acetylcholine receptor at the innervated membrane.

Sequence

MSHEKNEASGNPEAQSWKAQEAMLGVKTEVSRWRAVKNCLYRHLVKVLGEDWIFLLLLGALMALVSWAMDFIGSRGLRFYKYLFAMVEGNLGLQYLVWVCYPLILILFSSLFCQIVSPQAVGSGIPELKTIIRGAVLHEYLTLRTFVAKTVGLTVALSAGFPLGKEGPFVHIASICATLLNQLLCFISGRREEPYYLRADILTVGCALGISCCFGTPLAGVLFSIEVTCSHFGVRSYWRGFLGGAFSAFIFRVLSVWVKDTVTLTALFKTNFRGDIPFDLQELPAFAIIGIASGFFGALFVYLNRQIIVFMRKKNFVTKILKKQRLIYPAVVTFVLATLRFPPGVGQFFGAGLMPRETINSLFDNYTWTKTIDPRGLGNSAQWFIPHLNIFIVMALYFVMHFWMAALAVTMPVPCGAFVPVFNLGAVLGRFVGELMALLFPDGLVSNGNLYHILPGEYAVIGAAAMTGAVTHAVSTAVICFELTGQISHVLPMMVAVILANMVAQGLQPSLYDSIIQIKKLPYLPELSWSSANKYNIQVGDIMVRDVTSIASTSTYGDLLHVLRQTKLKFFPFVDTPETNTLLGSIERTEVEGLLQRRISAYRRQPATAAEAEEEGRNGERGASFTGDVPGEAETSFAYIDQEEAEGQQQREGLEAVKVQTEDPRPPSPVPAEEPTQTSGIYQKKHKGTGQVASRFEEMLTLEEIYQWEQREKNVVVNFETCRIDQSPFQLVEGTSLQKTHTLFSLLGLDRAYVTSMGKLVGVVALAEIQAAIEGSYQKGFRLPPPLASFRDAKNARNSGRTATSNSSGK

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

BINDING 123; /ligand="chloride" ; BINDING 418; /ligand="chloride" ; BINDING 512; /ligand="chloride"

Disease

Location

DOI ID

10.1016/0167-4781(91)90228-e; 10.1021/bi00249a005; 10.1126/science.1082708